New discovery could help improve cannabis cultivation

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A biosynthesis company has uncovered an enzyme that can assist cannabis production

Biosynthesis technology company Xinteza API Ltd. recently revealed the discovery of a new catalyst enzyme. This enzyme can solve one of the major bottlenecks in the design of cost-effective and sustainable cannabinoid production systems. It was discovered by Professor Asaph Aharoni of the Weizmann Institute of Science.

Xinteza has just unveiled new discoveries to a patent-pending, non-cannabis source for cannabinoid-biosynthesis-related genes and enzymes. This gene pool contains a new prenyl transferase enzyme.

Prenylation is the final and most important step in cannabinoid-biosynthesis. It forms CBGA, which is the “mother” molecule for many other cannabinoids like THCA and CBDA. However, the original enzyme that was used in cannabis sativa plants loses a significant amount of its activity when it’s introduced into yeast or bacteria expression systems.

Many alternative genes were suggested by research groups over the years to avoid this prenylation roadblock. However, most of these alternatives suffered from severe usability issues such as impaired chemical and freedom-of-operate issues or impaired chemical kinetics.

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The company claims that the new prenyltransferase enzyme PTX is able to solve this problem by providing improved catalytic activity in the range of 5-fold higher than the original cannabis sativa, and high compatibility for incorporation into micro-organisms-based cannabinoid industrial production systems.